Policies and guidance for researchers
体育直播站this page provides an overview of policies and guidance relating to good research practice and research integrity. it also provides access to resources and important policies that all mrc-funded scientists, including clinical researchers, are required to follow as a condition of their funding.
On this page:
- Research integrity, rigour and reproducibility
- Policies and guidance for researchers
- MRC Ethics Series
体育直播站all research funded by the mrc must be conducted to the highest standards of rigour and integrity throughout the research process, from initial planning to reporting and dissemination of results. we have developed various policies and resources to promote and support these high standards and commit to ensuring that our own internal processes and practices help to improve the reproducibility and rigour of the research which we fund.
our commitments to research integrity and the responsibilities of researchers and research organisations are outlined in the following documents.
in accordance with our commitments under the concordat we issue annual research integrity statements.
Research integrity contact: Dr Frances Rawle, Head of Corporate Governance and policy: email@example.com
Rigour and reproducibility
It is critical that the published results of biomedical and health research are reliable and reproducible if they are to support further scientific progress or translation into new treatments, diagnostics or preventive interventions to improve health. In 2015 we jointly sponsored a symposium “” which identified some causes of irreproducibility and possible measures for improvement. We have reviewed our policies and processes and have introduced a number of changes aimed at promoting rigorous research and improving reproducibility. An update on what we and other funders have done following the symposium and can be viewed in the Reproducibility update from sponsors (PDF, 184KB)document.
Improved peer review of methodology in funding applications:
as indicated in our has been developed to clarify what is required. a workshop on the importance of statistical methodology and experimental design is now part of the induction programme for new members of our research boards and panels.
We have provided particularly detailed guidance and some worked examples (PDF, 60KB)体育直播站 of how experimental design issues should be addressed in applications for research involving animals, and encourage applicants to consider using the online developed by the NC3Rs.
Doctoral training requirements:
mrc-funded phd students are expected to receive a comprehensive programme of research and skills training. the was revised in september 2016 and now includes a new requirement for training in experimental design and statistics and in the importance of ensuring research results are robust and reproducible. we are working with the leaders of mrc funded phd programmes to identify good practice in training provision as well as perceived gaps and how to address them.
Reporting research results and availability of data.
Greater transparency of methods and availability of data can make an important contribution to improving reproducibility. The MRC requires researchers that we fund to follow relevant reporting guidelines that have been developed to improve the design, analysis and reporting of experiments, such that readers can assess the robustness of the findings and reproduce the work if they wish. Examples are the guidance for animal research and for clinical trials. The sets out our expectations with regard to making data available, and we have recently updated our requirements for openness in relation to clinical and population health research (PDF, 171KB) and endorsed from publicly funded clinical trials developed by the MRC Methodology Hubs.
Quality control of experimental materials and procedures
The use of biological reagents and materials, such as antibodies and cell lines, can be a significant source of variability in biomedical experiments. Good laboratory quality control practices and the use of reliable resources such as cell and tissue banks with exemplary quality control can make an important contribution to promoting reproducibility, as can the use of specialist facilities. The MRC has supported a number of such resources and facilities which researchers are encouraged to use.
The MRC takes all cases of research misconduct seriously and requires that allegations related to MRC funded research are investigated appropriately. Allegations of research misconduct against MRC staff are investigated in accordance with our policy (PDF, 309KB). Allegations relating to MRC-funded research carried out in Universities or other organisations should be reported to, and investigated by, the relevant employer. Research Organisations must inform the MRC about allegations of research misconduct involving people in receipt of MRC funding or involved with the MRC in any other way (for example as a peer reviewer or a panel member), at the time they decide to undertake a preliminary investigation.
If you have any questions about how to raise a concern about research misconduct or wish to inform the MRC about an allegation under investigation please contact Dr Frances Rawle, Head of Corporate Governance and Policy: firstname.lastname@example.org.
these policies and resources support our good research practice guidelines.
- Data sharing
- Framework on the feedback of health-related findings in research
- Global bioethics
- Guidance on patient consent
- Managing the risk of research misuse
- Open access policy
- Open research data: clinical trials and public health interventions
- MRC Review of Clinical Trials
- Policy on clinical trials regulations governance
- Policy on health departments research governance framework
- Research and governance standards for UK-China research collaborations (CURE report 2009) (PDF, 1.47MB)
- Research involving animals
- Research involving cohort resources
- Research using human samples
- Sharing research data from population and patient studies (PDF, 763KB)
in addition to policies and resources that support good research practice and research integrity, the mrc ethics series guides address regulatory and ethical considerations relating to research.
- Human tissue and biological samples for use in research (2014) (PDF, 2.06MB)
- [For reference only. This guide has been withdrawn and replaced with the guidance '' above]
- Guidelines for the management of global health trials (2017) (PDF, 424KB)
- [For reference only. This guide has been withdrawn and replaced with the 'Guidelines for the management of global health trials (PDF, 424KB)' above]
If you have any queries about guides currently identified as for reference only please contact us at email@example.com